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Using OxyContin with medicines which can be CYP3A4 inhibitors or discontinuation of CYP3A4 inducers can result in a fatal overdose of oxycodone.Multiply total day by day dose of prior opioid by the conversion aspect (CF) offered under to acquire oxycodone dose in mg/day; divide oxycodone mg/day dose by two for getting twelve-hour oxycodone ER dose;